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Literature summary extracted from

  • Vyas, R.N.; Meredith, D.; Lane, R.P.
    Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line (2017), Mol. Cell. Neurosci., 82, 1-11 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.65 additional information RNAi knockdown of LSD1 expression leads to undetectable levels in about 90% of olfactory-placode-derived cell line (OP-6) cells in culture, modeling. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations, overview Mus musculus
1.14.99.66 additional information RNAi knockdown of LSD1 expression leads to undetectable levels in about 90% of olfactory-placode-derived cell line (OP-6) cells in culture, modeling. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.65 nucleus
-
 Mus musculus 5634
-
1.14.99.66 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?
1.14.99.66 [histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Mus musculus Q6ZQ88
-
-
1.14.99.66 Mus musculus Q6ZQ88
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.65 olfactory receptor neuron olfactory-placode-derived cell line, OP-6 Mus musculus
-
1.14.99.66 olfactory receptor neuron olfactory-placode-derived cell line, OP-6 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 additional information the bifunctional enzyme catalyzes the demethylation of H3K4me2/me1 (EC 1.14.99.66) and H3K9me2/me1 Mus musculus ?
-
 ?
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.65 [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
1.14.99.66 additional information the bifunctional enzyme catalyzes the demethylation of H3K4me2/me1 and H3K9me2/me1 (EC 1.14.11.65) Mus musculus ?
-
 ?
1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?
1.14.99.66 [histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 KDM1A
-
 Mus musculus
1.14.11.65 LSD1
-
 Mus musculus
1.14.11.65 lysine-specific demethylase-1
-
 Mus musculus
1.14.99.66 KDM1A
-
 Mus musculus
1.14.99.66 LSD1
-
 Mus musculus
1.14.99.66 lysine-specific demethylase-1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.65 FAD dependent on Mus musculus
1.14.99.66 FAD dependent on Mus musculus

General Information

EC Number General Information Comment Organism
1.14.11.65 malfunction depletion of LSD1 in an immortalized olfactory-placode-derived cell line (OP6) results in multigenic and multiallelic odorant receptor (OR) transcription per cell, while not seemingly disrupting the ability of these cells to activate new OR genes during clonal expansion. LSD1 depletion does not seem to alter OR representation in OP6 cell populations. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations Mus musculus
1.14.11.65 physiological function function of the mammalian olfactory system depends on specialized olfactory sensory neurons (OSNs) that each express only one allele of one odorant receptor (OR) gene (monogenic). The lysine-specific demethylase-1 (LSD1) has a role in silencing additional OR alleles in the immortalized olfactory-placode-derived cell line (OP6) cellular context. LSD1 protein removes activating H3K4 or silencing H3K9 methylation marks in a variety of developmental contexts Mus musculus
1.14.99.66 malfunction depletion of LSD1 in an immortalized olfactory-placode-derived cell line (OP6) results in multigenic and multiallelic odorant receptor (OR) transcription per cell, while not seemingly disrupting the ability of these cells to activate new OR genes during clonal expansion. LSD1 depletion does not seem to alter OR representation in OP6 cell populations. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations Mus musculus
1.14.99.66 physiological function function of the mammalian olfactory system depends on specialized olfactory sensory neurons (OSNs) that each express only one allele of one odorant receptor (OR) gene (monogenic). The lysine-specific demethylase-1 (LSD1) has a role in silencing additional OR alleles in the immortalized olfactory-placode-derived cell line (OP6) cellular context. LSD1 protein removes activating H3K4 or silencing H3K9 methylation marks in a variety of developmental contexts Mus musculus